Description: This is a 10 week research study in which all subjects will receive duloxetine (Cymbalta).The purpose of the research study is to examine how treatment with duloxetine may affect symptoms related to Panic Disorder.

Inclusion Criteria:
People who are between the ages of 18 and 65, who are experiencing symptoms of Panic Disorder and who are not currently taking another psychiatric medication may be eligible for this study. Women who are pregnant or breastfeeding or who are not on an approved form of contraception will not be eligible. People with a history of bipolar disorder, schizophrenia, or other psychotic conditions are excluded. People with severe and/or uncontrolled medical problems or acute narrow-angle glaucoma are excluded. People currently receiving psychotherapy directed towards the treatment of anxiety are also ineligible to participate.